Wegovy, Ozempic and Semaglutide

Wegovy® and Ozempic® are what everyone’s talking about, advertised on all television channels and pouring through social media. Semaglutide is the generic name for both Wegovy™ and Ozempic™. 

Sixty Minutes kicked off their 2023 season highlighting Semaglutide’s weight loss benefits demonstrated in impressive clinical results, but since early 2022  Wegovy™ has been dragged down by its high cost and supply chain issues making it almost impossible to get, even for diabetic patients who’ve been prescribed this medication for years prior.

Express Weight Loss and Wellness clinic has partnered with a compounding pharmacy and solved these concerns, providing the same higher dose Semaglutide while lowering its price, and it’s available today


A bit a history to bring us to where we’re at today:

2017:  Semaglutide was introduced for type-2 diabetes management, sold under the brand Ozempic™. 

2021:  FDA approved Wegovy, containing higher volumes of Semaglutide, introduced for the treatment of weight loss when used in combination with lifestyle changes. 

2023: Express Weight Loss and Wellness partnered with U.S. compounding pharmacies, adding the benefits of Cyanocobalamin to their Semaglutide, while still utilizing the higher dosing protocol. 


The Science of Semaglutide supporting Weight Loss

Every day, the brain receives signals from different places in the body. Some of these signals called appetite hormones, help regulate your food intakeSemaglutide helps to promote weight loss by mimicking a hormone called glucagon-like peptide-1 (GLP-1). This slows down the gastric emptying (feeling fuller longer which reduces the desire for food intake) and increases insulin secretion, thereby increasing sugar metabolism (lowers blood sugar levels after you’ve eaten a meal).   

Your body is smart, and it wants to maintain homeostasis, meaning it doesn’t want anything to change! It will fight to keep things how they are, which includes fighting against weight loss in most cases. Your body is designed to survive times of famine by holding on to energy as fat when it senses a threat, so your best efforts to diet could be thwarted by your hunger hormones!  Since Semaglutide acts on the brain to suppress the appetite, it may help you adhere to a reduced-calorie diet. That means you could stop feeling hungry every time you try to lower your weight!  


Clinical Trials

Due to the amazing results that participants in multiple studies (double-blind, randomized, placebo-controlled studies) have shown, many people are calling semaglutide a miracle FDA approved weight loss drug

Adults taking WEGOVY had average loss of 35 lbs ~ 15% of body weight

Those on a PLACEBO had average loss of 6 lbs ~ 2.5% of body weight

With Ozempic®, clinical trials showed an average 6% reduction in weight after one year (adults with an average starting weight of 197 pounds on 1.0 mg semaglutide per week). 

Another 2021 study found “sustained, clinically relevant reduction in body weight” with 2.4 mg of semaglutide once weekly.

These are meaningful results; stretch beyond these benchmarks to achieve sustained weight loss of 15% or more

Results based off a 68-week medical study of 1,961 adults with obesity (BMI ≥30) and adults with excess weight (BMI ≥27) who also had weight-related medical problems, including high blood pressure or high cholesterol. People with type 2 diabetes were excluded.  The average starting weight for both groups was 232 lbs. Both groups were instructed to take medicine along with a reduced-calorie meal plan and increased physical activity. 7% of people taking Wegovy (92 people) left the medical study due to side effects, compared to 3.1% of people taking a placebo (20 people).  While taking Wegovy™ (Semaglutide), people not only lost weight but also kept it off.


What makes Express’ program Better

Express’ program is comprehensive:

In person, continuous coaching.  We don’t limit the time you spend with our medical staff and weight loss experts.  See us every day if it’s what you need!  

Lipotropic Injections (twice weekly).  Amino acids working to help metabolize fat  along with B vitamins to provide the supplements needed to accelerate weight loss while providing energy. 

Practitioner-supervised program.  Monthly consults with our Practitioner to monitor and adjust the protocol to ensure safe and effective results.

Intermittent Fasting Meal Plan.  We don’t simply send you on your way, suggesting you eat healthy.  We provide the path with a daily meal plan, developed by nutritionists, replacement options for flexibility, along with a book providing ideas on how you can achieve your best results. 


Who should use Semaglutide?  

Wegovy™ (Semaglutide) is for adults with obesity (BMI ≥30) or overweight (excess weight) (BMI ≥27) who also have weight-related medical problems, to help them lose weight and keep it off. Wegovy™ (Semaglutide) should be used with a reduced-calorie meal plan and increased physical activity.


What are possible adverse effects?

Wegovy™ (Semaglutide) may cause serious side effects, including:

  • Possible thyroid tumors, including cancer. Tell your healthcare provider if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer. In studies with rodents, Wegovy™ (Semaglutide) and medicines that work like Wegovy caused thyroid tumors, including thyroid cancer. It is not known if Wegovy™ (Semaglutide) will cause thyroid tumors or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in people.
  • Do not use Wegovy (semaglutide) with other semaglutide-containing products or other GLP-1 receptor agonist medicines
  • Do not use Wegovy™ (Semaglutide) if you or any of your family have ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC) or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
  • Do not use Wegovy™ (Semaglutide) if you have had a severe allergic reaction to semaglutide or any of the ingredients in Wegovy™ (Semaglutide).
  • Inflammation of your pancreas (pancreatitis). Stop using Wegovy and call your healthcare provider immediately if you have severe pain in your stomach area (abdomen) that will not go away, with or without vomiting. You may feel the pain from your abdomen to your back.
  • It is not known if Wegovy can be used safely in people with a history of pancreatitis.
  • Gallbladder problems. Wegovy may cause gallbladder problems, including gallstones. Some gallstones may need surgery. Call your healthcare provider if you have symptoms, such as pain in your upper stomach (abdomen), fever, yellowing of the skin or eyes (jaundice), or clay-colored stools.
  • Increased risk of low blood sugar (hypoglycemia) in patients with type 2 diabetes, especially those who also take medicines for type 2 diabetes, such as sulfonylureas or insulin. This can be both a serious and common side effect. Talk to your healthcare provider about how to recognize and treat low blood sugar and check your blood sugar before you start and while you take Wegovy. Signs and symptoms of low blood sugar may include dizziness or light-headedness, blurred vision, anxiety, irritability or mood changes, sweating, slurred speech, hunger, confusion or drowsiness, shakiness, weakness, headache, fast heartbeat, or feeling jittery.
  • Kidney problems (kidney failure). In people with kidney problems, diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration) which may cause kidney problems to get worse. You need to drink fluids to help reduce your chance of dehydration.
  • Serious allergic reactions. Stop using Wegovy and get medical help immediately if you have any symptoms of a severe allergic reaction, including swelling of your face, lips, tongue, or throat; problems breathing or swallowing; severe rash or itching; fainting or feeling dizzy or very rapid heartbeat.
  • Change in vision in patients with type 2 diabetes. Tell your healthcare provider if you have changes in vision during treatment with Wegovy.
  • You have an increased heart rate. Wegovy can increase your heart rate while you are at rest. Tell your healthcare provider if you feel your heart racing or pounding in your chest, and it lasts for several minutes.
  • Depression or thoughts of suicide. You should pay attention to any mental changes, especially sudden changes in your mood, behaviors, thoughts, or feelings. Call your healthcare provider right away if you have any mental changes that are new, worse, or worry you.
  • It is not known if Wegovy is safe and effective when taken with other prescription, over-the-counter, or herbal weight loss products.


Before using Wegovy™ (Semaglutide), tell your healthcare provider if you have any other medical conditions, including if you:

  • Have or have had problems with your pancreas or kidneys
  • Have type 2 diabetes and a history of diabetic retinopathy.
  • Have or have had depression, suicidal thoughts, or mental health issues.
  • Are you pregnant or plan to become pregnant? Wegovy may harm your unborn baby. You should stop using Wegovy™ (Semaglutide) 2 months before you plan to become pregnant.
  • Are you breastfeeding or planning to breastfeed? It is not known if Wegovy™ (Semaglutide) passes into your breast milk.


Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Wegovy may affect how some medicines work, and some drugs may affect the way Wegovy works. Tell your healthcare provider if you are taking other medicines to treat diabetes, including sulfonylureas or insulin. Wegovy slows stomach emptying and can affect medicines that need to pass through the stomach quickly.

The most common side effects of Wegovy™ (Semaglutide) may include nausea, diarrhea, vomiting, constipation, stomach (abdomen) pain, headache, tiredness (fatigue), upset stomach, dizziness, feeling bloated, belching, gas, stomach flu, or heartburn.